Conflict of interest information
The Authors have no conflicts of interest to declare.
Acknowledgment : This work was supported by funds from the Italian Ministry of Health (Finalised Research / Ricerca Finalizzata grant no. GR-2013-02358399) and Ricerca Corrente Fondazione IRCCS Policlinico San Matteo (grant n. 80206). We thank Daniela Sartori for manuscript editing.