Treatment
Data were extracted from hospital medical records, and demographic, clinical, treatment, and laboratory data were obtained. All patients who underwent liver transplantation were administered an anti-immune rejection regimen of tacrolimus and hormones on the first day after surgery. The initial dose of tacrolimus was 0.1-0.15 mg/kg/d, and the ideal blood concentrations were as follows: 1 month after transplantation, the serum concentration of tacrolimus should be maintained within 8-12 ng/mL; from 2-6 months post-operative, the serum concentration of tacrolimus should be maintained between 7-10 ng/mL before being reduced to 5-8 ng/mL at 7-12 months and maintained at 5 ng/mL, as appropriate, 12 months after transplantation. During this period, the drug dosage can be adjusted according to the tacrolimus blood drug concentration and EBV copy number. The total duration of hormone treatment was short. The first dose of glucocorticoid was intravenously administered during the non-hepatic stages of surgery. The dose of intravenous glucocorticoid was reduced to 4 mg/kg/d within 1 week post-operative and oral glucocorticoids (e.g. prednisone, an initial dose of 0.25-1 mg/kg/d) were administered 1 week after surgery. Patients with no abnormalities should stop glucocorticoid therapy at the earliest possible opportunity within 3-6 months after surgery.