The relationship between EBV-DNA peak time, PTLD onset time, and tacrolimus concentration in the PTLD group
In the PTLD group, a close relationship was observed between EBV-DNA peak time after transplantation and PTLD onset time (|r|=0.873, P<0.01); this suggests that PTLD is prone to occur during uncontrolled proliferation of EBV infection. (Table 5).
Analysis of the time between peak EBV-DNA and peak tacrolimus concentration suggested that the higher the blood concentration of tacrolimus, the more difficult it was to control EBV infection (|r|=-0.481, P<0.05). (Table 6).