Treatment
Data were extracted from hospital medical records, and demographic,
clinical, treatment, and laboratory data were obtained. All patients who
underwent liver transplantation were administered an anti-immune
rejection regimen of tacrolimus and hormones on the first day after
surgery. The initial dose of tacrolimus was 0.1-0.15 mg/kg/d, and the
ideal blood concentrations were as follows: 1 month after
transplantation, the serum concentration of tacrolimus should be
maintained within 8-12 ng/mL; from 2-6 months post-operative, the serum
concentration of tacrolimus should be maintained between 7-10 ng/mL
before being reduced to 5-8 ng/mL at 7-12 months and maintained at 5
ng/mL, as appropriate, 12 months after transplantation. During this
period, the drug dosage can be adjusted according to the tacrolimus
blood drug concentration and EBV copy number. The total duration of
hormone treatment was short. The first dose of glucocorticoid was
intravenously administered during the non-hepatic stages of surgery. The
dose of intravenous glucocorticoid was reduced to 4 mg/kg/d within 1
week post-operative and oral glucocorticoids (e.g. prednisone, an
initial dose of 0.25-1 mg/kg/d) were administered 1 week after surgery.
Patients with no abnormalities should stop glucocorticoid therapy at the
earliest possible opportunity within 3-6 months after surgery.