Figure 1. Sequence alignment of eukaryotic PPases with known
structures. The secondary structures present in human PPA1 are
indicated above the human PPA1 sequence, with α, η, and β for α helix,
310 helix, and β strand respectively. Numbering is for
the human PPA1 sequence. Residues involved in human PPA1 dimerization
are indicated with a red italic letter i above the sequence.
Active site residues important for catalysis in the yeast PPase are
indicated by a filled triangle. The sequence of P. falciparumPPase has a N-terminal extension of 76 residues (not shown).