Study |
Inclusion criteria and selection |
Index test cut-off |
Index test examiner |
Reference standard(s) |
Definition of CMPA by reference
standard |
CMPA questionnaire |
CMPA questionnaire |
CMPA
questionnaire |
CMPA questionnaire |
CMPA questionnaire |
CMPA questionnaire |
Gibbons, 2012 |
Case-control: infants < 2 years seen at
gastroenterology clinic with a diagnosis of CMPA & presumed healthy
controls seen at routine health visit |
ROC-determined: score
> 6 |
Health professional |
Elimination diet + ImmunoCAP |
Positive response to diet + test negative for IgE mediated disease +
failed management of alternative conditions |
CoMiSSTM (†or its earlier SBS
version)
|
CoMiSSTM (†or its
earlier SBS version)
|
CoMiSSTM
(†or its earlier SBS version)
|
CoMiSSTM (†or its earlier SBS
version)
|
CoMiSSTM (†or its
earlier SBS version)
|
CoMiSSTM
(†or its earlier SBS version)
|
Prasad, 2018 |
Infants aged 0-24 months seen at paediatric clinic with
one or more symptoms of CMPA, including cutaneous, respiratory, or GI |
Pre-specified: score > 12 |
General paediatrician |
OFC or
ImmunoCAP |
Positive if symptoms reappear within 2 weeks of OFC or IgE
mediated CMPA confirmed by ImmunoCAP |
Salvatore, 2019
|
Case-control: infants aged 1-12 months seen at gastroenterology clinic
with suspected CMPA and who started CMFD for persistent GI symptoms &
healthy controls
|
Pre-specified: score > 12;
ROC-determined: score > 9
|
Paediatrician
|
Response to CMFD
|
Change in CoMiSSTM score of symptomatic infants at
presentation to a score below the median of control population after 2-4
weeks CMFD
|
Sirin Kose, 2019†
|
Infants aged 0-10 months with a
diagnosis of CMPA or HEA or both presenting to paediatric allergy clinic
and with SBS > 12 |
Pre-specified: score > 12
with reduction of 25% or score > 10 with reduction
of 50% |
Medical supervision |
OFC or skin prick test in infants
< 6 months |
Positive if symptoms reoccur following OFC,
positive skin prick with wheal >3mm |
Vandenplas, 2014†
|
Infants aged 0-6 months presenting
with symptoms of mild to moderate CMPA and with SBS > 12 |
ROC-determined: score > 12 baseline to score < 6
after elimination |
Physician |
OFC |
Positive if symptoms reoccur
within 1 week of OFC |
Zeng, 2019 |
Infants aged 1-12 months seen at paediatric GI clinic for
suspected CMPA with at least one symptom, including anaphylaxis, GI,
respiratory and dermatological manifestations, and sIgE < 5.0
kU/L |
ROC-determined: score > 5.5 |
GI physician |
OFC |
Positive if symptoms reappear within 2 weeks of OFC |
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
HEA – hen’s egg allergy
GI – gastrointestinal
OFC – oral food challenge
ROC – receiver operating curve
sIgE – serum IgE
SBS – symptom-based score
|
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
HEA – hen’s egg allergy
GI – gastrointestinal
OFC – oral food challenge
ROC – receiver operating curve
sIgE – serum IgE
SBS – symptom-based score
|
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
HEA – hen’s egg allergy
GI – gastrointestinal
OFC – oral food challenge
ROC – receiver operating curve
sIgE – serum IgE
SBS – symptom-based score
|
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
HEA – hen’s egg allergy
GI – gastrointestinal
OFC – oral food challenge
ROC – receiver operating curve
sIgE – serum IgE
SBS – symptom-based score
|
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
HEA – hen’s egg allergy
GI – gastrointestinal
OFC – oral food challenge
ROC – receiver operating curve
sIgE – serum IgE
SBS – symptom-based score
|
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
HEA – hen’s egg allergy
GI – gastrointestinal
OFC – oral food challenge
ROC – receiver operating curve
sIgE – serum IgE
SBS – symptom-based score
|