Study Research objectives CoMiSSTM outcome measure Results (N = infants included in analysis;)
Dupont, 2016 Measure tolerance of eHCF in infants 1-12 months with confirmed CMPA At inclusion; day 14 N=30; mean CoMiSSTM decreased from 7.4 to 3.2 after 14 days. Mean CoMiSSTM at inclusion < 12.
Rossetti, 2019 Evaluate hypoallergenicity of TeHCF in infants 1-36 months with suspected or diagnosed CMPA At inclusion; day 7, day 45, day 90 N=29; mean CoMiSSTM at inclusion 1.4 ± 2.0. No significant difference in COMISSTMTM score after 7 days. Maximum score of 6 in 3/29 infants.
Vandenplas, 2013 Measure efficacy of eWH and eCH in infants 0.5-6 months with suspected CMPA Before challenge; at inclusion; 1, 2, 4, 6, 8, 10 months N=116; mean SBS at inclusion 13.6 ± 2.2 in eWH and 13.8 ± 1.5 in eCH. SBS decreased by -8.3 in eWH and -7.8 in eCH groups at 1 month. Decrease to < 2 in both groups by 10 months.
Vandenplas, 2014 Measure efficacy of eRHF in infants 0-6 months with suspected CMPA Before challenge; at inclusion; 1, 3, 6 months N=38; mean SBS 13.5 ±5.2 at inclusion. Significant decrease at each time point (p<0.001). Decrease to < 2 by 6 months.
Vandenplas, 2014 Evaluate hypoallergenicity of thickened versus non thickened eCH in infants < 6 months with suspected CMPA At inclusion; 1 month N=72; mean SBS 14.1 at inclusion. Decrease by -7.4 ± 5.5 after 1-month intervention. Statistically stronger decrease in CMPA+ group than CMPA- group (p<0.05).
CMPA – cow’s milk protein allergy eCH – extensive casein hydrolysate eHCF – extensively hydrolysed casein-based formula eRHF – extensive rice hydrolysate formula eWH – extensive whey hydrolysate SBS – symptom-based score (early version of CoMiSSTM) TeHCF – thickened extensively hydrolysed casein-based formula CMPA – cow’s milk protein allergy eCH – extensive casein hydrolysate eHCF – extensively hydrolysed casein-based formula eRHF – extensive rice hydrolysate formula eWH – extensive whey hydrolysate SBS – symptom-based score (early version of CoMiSSTM) TeHCF – thickened extensively hydrolysed casein-based formula CMPA – cow’s milk protein allergy eCH – extensive casein hydrolysate eHCF – extensively hydrolysed casein-based formula eRHF – extensive rice hydrolysate formula eWH – extensive whey hydrolysate SBS – symptom-based score (early version of CoMiSSTM) TeHCF – thickened extensively hydrolysed casein-based formula CMPA – cow’s milk protein allergy eCH – extensive casein hydrolysate eHCF – extensively hydrolysed casein-based formula eRHF – extensive rice hydrolysate formula eWH – extensive whey hydrolysate SBS – symptom-based score (early version of CoMiSSTM) TeHCF – thickened extensively hydrolysed casein-based formula