We present our experience in the management of children with
inflammatory myofibroblastic tumor, a total of five children with two
presenting with superior mediastinal syndrome and three with abdominal
disease. We treated all children with a low-dose oral chemotherapy
protocol, including prednisolone, 6-mercaptopurine, methotrexate, and
celecoxib. Children with the mediastinal disease showed complete
response with chemotherapy alone, while the child with sigmoid polyp is
in remission with the chemotherapy post complete excision. We commenced
two children with abdominal disease on crizotinib due to local
recurrence with an adequate response. Long term follow-up and prolonged
therapy are essential to sustain remission.