Study population
Participants with a partner in the reproductive age (18-45 year) were recruited in our genetic counseling and prenatal diagnosis center before pursuing genetic testing (mainly cell-free fetal DNA screening and peripheral blood karyotype before pregnancy) at Women’s Hospital of Nanjing Medical University from August 2019 to December 2019. Only participants who were planning a pregnancy or undergoing pregnancy, were living in China and had no mental or intellectual disabilities were qualified to our questionnaire.