Figure 1: Final
population PK model. θi individual parameter;
θp population parameter; ηi random
effect of between-subject variability; CLsys systemic
renal clearance, CLCRRT systemic clearance on CRRT, CLCr
creatinine clearance; CLCr~CL effect of creatinine
clearance on clearance; Vc central compartment volume of
distribution; WT body weight; Wt~Vc effect of body
weight on volume of
distribution
Figure 2: Probability of target attainment for an organism MIC
of a2 mg/L and b4 mg/L over time of
tested fluconazole dosing regimens in critically ill adult patients
stratified by weight and renal
function.