Figure 1: Final population PK model. θi individual parameter; θp population parameter; ηi random effect of between-subject variability; CLsys systemic renal clearance, CLCRRT systemic clearance on CRRT, CLCr creatinine clearance; CLCr~CL effect of creatinine clearance on clearance; Vc central compartment volume of distribution; WT body weight; Wt~Vc effect of body weight on volume of distribution
Figure 2: Probability of target attainment for an organism MIC of a2 mg/L and b4 mg/L over time of tested fluconazole dosing regimens in critically ill adult patients stratified by weight and renal function.