Outcomes Overall
(n = 80) Overall
(n = 80) ASTRALI group
(n = 40) ASTRALI group
(n = 40) ASTRALI group
(n = 40) Control group
(n = 40) Control group
(n = 40) p value
No. % No. No. % No. %
CRP (T0) mg/L 164 ± 67.787 164 ± 67.787 177 ± 79.931 177 ± 79.931 177 ± 79.931 151 ± 50.604 151 ± 50.604 0.082
CRP (T96) mg/L 76 (50) 76 (50) 68 (55) 68 (55) 68 (55) 89 (56) 89 (56) 0.033*
IL-1β (T0) mg/L 12.9 ± 5.091 12.9 ± 5.091 12.4 ± 4.835 12.4 ± 4.835 12.4 ± 4.835 13.5 ± 5.346 13.5 ± 5.346 0.364
IL-1β (T96) mg/L 11.6 ± 5.408 11.6 ± 5.408 11.7 ± 5.338 11.7 ± 5.338 11.7 ± 5.338 11.4 ± 5.539 11.4 ± 5.539 0.796
IL-8 (T0) pg/mL 40.0 ± 17.001 40.0 ± 17.001 38.1 ± 17.624 38.1 ± 17.624 38.1 ± 17.624 41.9 ± 16.349 41.9 ± 16.349 0.316
IL-8 (T96) pg/mL 18.9 (23.9) 18.9 (23.9) 11.8 (7.3) 11.8 (7.3) 11.8 (7.3) 35.5 (19.8) 35.5 (19.8) <0.0001*
IL-10 (T0) pg/mL 15.1 ± 5.752 15.1 ± 5.752 14.1 ± 5.411 14.1 ± 5.411 14.1 ± 5.411 16.1 ± 5.967 16.1 ± 5.967 0.114
IL-10 (T96) pg/mL 24.7 (17.3) 24.7 (17.3) 31.6 (25.8) 31.6 (25.8) 31.6 (25.8) 17.7 (12.0) 17.7 (12.0) <0.0001*
SOD (T0) U/L 8758 ± 4149 8758 ± 4149 8493 ± 4489 8493 ± 4489 8493 ± 4489 9023 ± 3819 9023 ± 3819 0.571
SOD (T96) U/L 10272 (8621) 10272 (8621) 12876 (4627) 12876 (4627) 12876 (4627) 5895 (6632) 5895 (6632) <0.0001*
MDA (T0) µM/L 0.29 ± 0.055 0.29 ± 0.055 0.28 ± 0.0553 0.28 ± 0.0553 0.28 ± 0.0553 0.30 ± 0.0535 0.30 ± 0.0535 0.302
MDA (T96) µM/L 0.211 (0.063) 0.211 (0.063) 0.197 (0.034) 0.197 (0.034) 0.197 (0.034) 0.234 (0.074) 0.234 (0.074) 0.002*
VC (T0) mg/L 3.6 ± 0.988 3.6 ± 0.988 3.4 ± 1.021 3.4 ± 1.021 3.4 ± 1.021 3.9 ± 0.945 3.9 ± 0.945 0.300
VC (T48) mg/L 22.2 ± 92.48 22.2 ± 92.48 94.9 ± 43.35 94.9 ± 43.35 94.9 ± 43.35 3.0 ± 1.30 3.0 ± 1.30 <0.0001*
VC (T96) mg/L 53.0 (126.40) 53.0 (126.40) 130.5 (111.65) 130.5 (111.65) 130.5 (111.65) 4.2 (2.37) 4.2 (2.37) <0.0001*
VC (T120) mg/L 19.3 (47.50) 19.3 (47.50) 50.4 (29.98) 50.4 (29.98) 50.4 (29.98) 3.8 (0.62) 3.8 (0.62) <0.0001*
VC (T144) mg/L 3.4 (0.95) 3.4 (0.95) 3.2 (1.95) 3.2 (1.95) 3.2 (1.95) 3.5 (0.87) 3.5 (0.87) 0.739
P/F ratio (T0) 161 (79) 161 (79) 157 (62) 157 (62) 157 (62) 170 (102) 170 (102) 0.115
P/F ratio (T24) 200 (83) 200 (83) 203 (79) 203 (79) 203 (79) 191 (103) 191 (103) 0.073
P/F ratio (T48) 229 (64) 229 (64) 233 (61) 233 (61) 233 (61) 218 (70) 218 (70) 0.003*
P/F ratio (T72) 255 (84) 255 (84) 298 (67) 298 (67) 298 (67) 233 (36) 233 (36) <0.0001*
P/F ratio (T96) 289 (125) 289 (125) 342 (39) 342 (39) 342 (39) 234 (57) 234 (57) <0.0001*
MV days 5 (3) 5 (3) 4 (3) 4 (3) 4 (3) 5 (3) 5 (3) 0.611
ICU days 7 (6) 7 (6) 8 (6) 8 (6) 8 (6) 7 (6) 7 (6) 0.649
VP days 3 (5) 3 (5) 1 (4) 1 (4) 1 (4) 4 (5) 4 (5) 0.019*
7 days-mortality 23 28.8 6 15 15 17 42.5 0.013*
28 days-mortality 33 41.3 13 32.5 32.5 20 50.0 0.173
Hypernatremia 4 5.0 3 7.5 7.5 1 2.5 0.615
AKI 9 11.3 4 10.0 10.0 5 12.5 1.000