Contributing factors for submission of presumed PLPVs to
ClinVar
To assess the factors that influence submission of the presumed PLPV to
ClinVar, multivariate logistic regression analysis was performed. The
following variables correlated with submission of presumed PLPV to
ClinVar: higher allele counts (X1), whether presumed PLPVs were detected
in the Non-Finnish European population (X2), whether these PLPVs inTSHB (X3) were present, and whether these PLPVs in TG (X4)
were absent (Table 2). The equation for this model is:
Ln(\(\frac{P}{1-P}\)) = -3.461 +
0.129 * X1 + 1.331 * X2 + 1.934 * X3 – 0.882 * X4