Database analysis
The gnomAD data (v2.1.1) was obtained from https://gnomad.broadinstitute.org/. A total of 10 candidate genes that follow an autosomal recessive inheritance pattern in congenital hypothyroidism (SLC5A5 , TPO , TG , IYD ,DUOXA2 , DUOX2 , TSHR , TSHB , TRHR ,FOXE1 ) were analyzed. The gnomAD database (v2.1.1) contains genetic variants from 125,748 exomes and 15,708 genomes and eight populations, including African/African American, Latino Ashkenazi Jewish, East Asian, Finnish, Non-Finnish European, South Asian, and other groups.