Comparison of the two methods for analysis of carrier frequency
and predicted genetic prevalence
The carrier frequency for a variant (CFV) was calculated
based on the allele frequency of each heterozygous PLPV except
homozygous carriers. The CFG and pGPGwere analyzed using two different methods as described in the methods
section for every gene in each ethnic group, and the CFGand pGPG values calculated by the two methods were
compared. Notably, linear regression analysis showed a perfect fit:
R2=1 (y = 0.00001814 + 0.990x) for CFG(Figure 1A) and R2=1 (y = 0.0000001347 + 0.961x) for
pGPG (Figure 1B).