Contributing factors for submission of presumed PLPVs to ClinVar
To assess the factors that influence submission of the presumed PLPV to ClinVar, multivariate logistic regression analysis was performed. The following variables correlated with submission of presumed PLPV to ClinVar: higher allele counts (X1), whether presumed PLPVs were detected in the Non-Finnish European population (X2), whether these PLPVs inTSHB (X3) were present, and whether these PLPVs in TG (X4) were absent (Table 2). The equation for this model is:
Ln(\(\frac{P}{1-P}\)) = -3.461 + 0.129 * X1 + 1.331 * X2 + 1.934 * X3 – 0.882 * X4