Maternal CVD risk factors according to the delivery of an infant
with intrauterine growth restriction vs women who experienced
uncomplicated pregnancies
Two studies compared maternal CVD risk factors between women who gave
birth to growth restricted infants and women who had uncomplicated
pregnancies13, 14 (table 1). Of these one study was
conducted on normotensive women who gave birth to growth restricted
infants14. Manten and colleagues reported a
significantly higher serum total cholesterol level among women who gave
birth to infants diagnosed as having IUGR compared to women who had
uncomplicated pregnancies but the difference was not significant after
excluding women with chronic hypertension, smokers and those with BMI
> 30kg/m213 (table 1). Yinon and
colleagues compared BMI, total cholesterol, LDL, HDL, blood glucose and
insulin in women who gave birth to growth restricted infants and those
who had uncomplicated pregnancies14. Both studies were
included in meta-analyses on BMI, total cholesterol, HDL cholesterol and
triglycerides13, 14. The pooled analyses showed that
women who gave birth to infants diagnosed as having IUGR had
significantly higher mean BMI (1.72kg/m2, 95% CI 0.97
to 2.47; 77 participants, heterogeneity: Chi2 P 0.35;
I2 = 0%, figure 2A), and higher total mean
cholesterol levels (0.32mmol/l, 95% CI 0.13 to 0.50; 77 participants,
heterogeneity: Chi2 P 0.69; I2 =
0%) compared to women who had uncomplicated pregnancies (figure
2B)13, 14.