Introduction
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic
stem-cell disorder that is characterized by hemolytic anemia,
bone-marrow failure, and thrombosis.1 Thromboembolism
in PNH is associated with poor prognosis and is a leading cause of
death.2, 3 Making prompt diagnosis of thrombosis is
important to help determine treatment for patients with
PNH.4 However, making the diagnosis is sometimes
challenging, partly because of caregivers’ unfamiliarity with its
clinical manifestations. Despite the high frequency of intraabdominal
thrombosis in PNH,2 reports of upper gastrointestinal
manifestations of thrombotic complications are rare.5Here, we report a patient with PNH who developed gastric and duodenal
lesions likely caused by transient mucosal ischemia due to PNH-related
thrombosis. This case report was prepared according to the CARE
Guidelines.6