IVIG treatment significantly reduced the production of
anti-collagen antibodies in CIA mice
IVIG is known to consist neutralizing antibodies targeting the Fab
portion of pathogenic autoantibodies, a phenomenon previously described
as an anti-idiotypic activities. Therefore, we analyzed the effect of
IVIG in amelioration of anti-collagen antibodies in the plasma of CIA
mice ±treatment (Fig.4).
As illustrated in Fig.4, ELISA examination of antibodies against
collagen in IVIG-CIA group showed OD of 1.15±0.28 at 405nm, as compared
to 1.56±0.31 OD and 1.76 ±0.7 OD in PBS or untreated CIA mice,
respectively, P <0.001.