Figure 3. Functional classification of the proteins differentially expressed in the olfactory neuroepithelium (ON) cells from cannabis users. Differentially expressed proteins were analyzed with the Ingenuity Pathways Analysis (IPA) software. (A)Proteins differentially expressed are involved in 30 canonical pathways, sorted by the p-values assigned by IPA. These pathways have p-values above the red line threshold and thus, they are predicted to be affected. The ratio indicates the number of differentially expressed proteins found relative to the total number of proteins involved in the pathway. (B ) The proteins differentially expressed that are involved in the diseases and functions are indicated. The p-value range and number of proteins involved in each disease or activity are included.