Figure 4. Graphical correlations between differentially
expressed proteins in olfactory neuroepithelium (ON) cells from cannabis
users and their main related functions or diseases . The pathways were
obtained from the Ingenuity Pathways Analysis (IPA) software. The
proteins differentially expressed in the ON cells from cannabis users (p
< 0.05) are involved in: (A) cell morphology and
microtubules dynamics, (B ) cell death, (C) cell growth
and proliferation, and (D) hereditary and/or developmental
neurological disorders. Proteins with enhanced expression are indicated
in red and the more weakly expressed proteins are indicated in green.
Based on the literature and databases, the functions that are predicted
to be activated or inhibited are labelled in orange or blue,
respectively. The type of proteins, functions or diseases are indicated
by different shape icons. MED: Microcephaly, epilepsy and diabetes
syndrome.