Figure 4. Graphical correlations between differentially expressed proteins in olfactory neuroepithelium (ON) cells from cannabis users and their main related functions or diseases . The pathways were obtained from the Ingenuity Pathways Analysis (IPA) software. The proteins differentially expressed in the ON cells from cannabis users (p < 0.05) are involved in: (A) cell morphology and microtubules dynamics, (B ) cell death, (C) cell growth and proliferation, and (D) hereditary and/or developmental neurological disorders. Proteins with enhanced expression are indicated in red and the more weakly expressed proteins are indicated in green. Based on the literature and databases, the functions that are predicted to be activated or inhibited are labelled in orange or blue, respectively. The type of proteins, functions or diseases are indicated by different shape icons. MED: Microcephaly, epilepsy and diabetes syndrome.