Conclusion
Thus, our proposals for nomenclature and classification of allergy
include the following points:
1. Pathologically altered body reactivity can be of two types:
increased, hyperreactive – allergy, and reduced – anergy.
2. Allergy includes two reaction stages: 1) hypersensitivity (without
clinical manifestations) and 2) hyperreactivity with clinical symptoms.
3. A specific immunologically mediated allergy depends on the presence
of antibodies of different isotypes and immune T and B lymphocytes to
the allergen.
4. Nonspecific allergy is hypersensitivity and hyperreactivity of the
immune system and any cells, as well as humoral systems, to the
pathogen.
5. Anergy is the second type of pathologically altered reduced
reactivity, and it can be allergen-specific (immune) and non-immune. A
kind of antigen-specific anergy to an infection agent may be immunity
itself, although at first glance it seems absurd. But normergia is a
normal immune response to infection, while hyperergic reponse is a
disease.