Figure 3 - A novel neutrophil subgroup in asthma
In humans, neutrophils released from the bone marrow that
express low levels of CD16 and high levels of CD62L. This
CD16dimCD62Lhigh subset is
considered representing immature neutrophils whereas the
CD16highCD62Ldim subset is thought
to be mature and induces systemic inflammation. Also, their frequency
increases in the blood after the bronchoprovocation test. In allergic
asthmatics, neutrophils upregulate surface CD47 and simultaneously
downregulate surface CD36 and CD43. The phagoptosis signals may play a
role in prolonging neutrophil survival and asthma severity. CD62L;
cluster of differentiation 62 Ligand.