Figure 3. Highly activated Mo/Mac clusters in COVID-MDR and interactionanalyses.
A, Boxplots depicting the fraction of the indicated CD8+ T cell clusters (upper graph) and CD4+ T cell clusters (lower graph) among total cells in the different conditions (COVID-MDR, DRESS, MDR, HC). B,Heatmap of z-scored average expression for each marker of the clustered CD8+ T cells (left 4 columns) and CD4+ T cells clustered (right 4 columns). C,Heatmap of z-scored average marker expression of Mo/Mac clustered cells.D, Boxplots represent the fraction of the 4 Mo/Mac clusters among total cells in the different conditions (COVID-MDR, DRESS, MDR, HC). E, Circular string graph showing interactions between the main identified cell types in COVID-MDR, DRESS, MDR and HC (pooled per indication). We excluded Keratinocytes from the plot and also excluded one MDR sample which contained very high numbers of Neutrophils. The cell-types are individually colored and labelled on the outside of the plot. The number of interactions is also given on the outside of the plot. Interactions are depicted ingoing and outgoing for each cell-type.