Cell-cell contacts in COVID-MDR, DRESS and MDR are comparable to
HC skin
We investigated the cellular contacts amount the cell-types classified
in this dataset and compared them to HC samples (Figure 3E). Overall,
the patterns of interaction between the indications were very similar.
Despite the large differences in interaction counts, we did not observe
interactions that were absent in any of the indications while present in
another. We also applied our previously published neighborhood algorithm
and could not detect recurrent significant changes (data not shown). We
conclude that the overall cellular interactions in drug rashes stay
intact given that larger amounts of immune cells are present.