Association of VTA RFs with outcomes in CRT-D patients without LBBB
Figure 1A shows that among non-LBBB patients with CRT-D, the 4-year cumulative probability of VTA was significantly higher among those with ≥1 RF when compared to those without RF (40% vs. 14%, p<0.001, respectively). Similarly, patients with ≥1 RF experienced a significant higher rate of the secondary outcomes measures of VTA or death (51% vs. 22%, respectively log-rank p<0.001 for the overall difference during follow-up [Figure 1B]) and appropriate ICD shock (28% vs. 7%, respectively; p=0.002 [Figure 1C]).
The results of the CRT-D-only multivariate Cox regression models are presented in Table 1. Among non-LBBB patients with CRT-D, the presence of one or more RF was associated with >3.5-fold (p<0.001) increased risk for VTA compared with no RF. Furthermore, patients who had 2 or more RF experienced a >9-fold (p<0.001) increased risk for VTA compared with those with no RF. Similar results were shown for the secondary endpoints of VTA/death and appropriate ICD shock (Table 1).