Conclusions and clinical implications
Our study suggests that baseline factors that are associated with increased risk for VTA can be used to identify non-LBBB patients in whom CRT-D may associated with beneficial vs. proarrhythmic effects. These findings, if appropriately validated in similar populations of CRT-D recipients and larger studies, may be used for improved selection of patients with non-LBBB for cardiac resynchronization therapy with a defibrillator vs. ICD-only therapy.