Use of a ventilator
Among pertinent studies, there was no significant association between these outcomes and the use of ACEIs/ARBs (OR:1.49; 95%CI: 0.80, 2.77; OR: 1.26; 95%CI: 0.84, 1.80), ACEIs (OR:1.01; 95%CI:0.03, 34.76; OR:1.15; 95%: 0.55, 2.38), or ARBs (OR:0.98; 95%CI: 0.08, 11.57; OR: 1.48; 95%CI: 0.91, 2.38) (Figure 9; Figure 10; Table 3). However, a significantly higher odds of ventilator use with ACEIs/ARBs among the European studies (OR: 3.34; 95%CI: 2.04, 5.48) and the USA (OR:1.52; 95%CI:1.17, 1.98) in contrast to significantly lower odds among those from Asia (OR:0.2; 95%CI: 0.04, 0.95) (Supplementary file 9Table 4). Contrastingly, a significantly higher odds of ventilator use with ACEIs/ARBs was only observed among non-peer reviewed studies (OR:3.34; 95%CI: 2.04, 5.48) (Supplementary file 9Table 1).