Host factors involved in PEDV infection
It is well known that viral infection is a multi-step process including
adsorption, cell entry, dehulling, biosynthesis, assembly, and release,
etc. Besides the viral proteins of PEDV, the implication of numerous
host factors including receptors in these processes has been confirmed,
which is described as following in accordance with the infection stages.
Attachment and Entry
Adsorption of viruses to the host cells is the first and decisive step
for determining the virus tropism, namely the ability of different
viruses to infect various cell types. Correspondingly, virus-specific
receptors on the host cell surface are tightly related to the tissue
tropism and host range, and mediate the entrance of viruses including
PEDV into the host cells.