Summary
Porcine
epidemic diarrhea virus (PEDV), a coronavirus pathogen of the pig
intestinal tract, can cause fatal watery diarrhea in piglets, thereby
leading huge economic losses to
swine
industry around the world. The pathogenesis of PEDV has been intensively
studied, however, the viral proteins of PEDV and the host factors in
target cells, as well as their interactions, which underly the molecular
mechanisms of viral infection, remains to be illustrated and summarized.
PEDV has multiple important structural and functional proteins which
play various roles in the process of virus infection. Among them, the S
and N proteins play vital roles in biological processes related to PEDV
survival via interacting with the host cell proteins. Vice versa, a
number of host factors including receptors are required for the
infection of PEDV per the interactions with the viral proteins, thereby
affecting the reproduction and contributing to the life cycle of PEDV.
In this review, we intend to provide an update understanding of the PEDV
viral proteins and host factors and illustrate the interactions between
them. Additionally, the effects of cellular factors or events or
signaling pathways on PEDV infection are also
discussed. Thus, these
comprehensive and creative insights should facilitate to guide the
future research, control and prevention of PEDV infection.
Keywords: Porcine epidemic diarrhea virus (PEDV); Host factors;
Viral proteins; Viral infection; Interaction