Figure legend:
Fig 1: The involvement of numerous host factors and viral
proteins in the different processes of PEDV infection . During the
process of virus attachment and entry into cells, the host factors pAPN,
HS, sialic acid, EGFR, TMPRSS2, MSPL and occludin
are found to promote PEDV
infection by interacting with the S protein. DC-SIGN and DPP4 may play a
role in this process as well, while more robust evidence is needed.
HnRNPA1 and NPM1 are verified to
interact with the N protein of PEDV, thus participating in the
transcription and replication stages.
Finally, TMPRSS2 and BST2 are
identified to take part in the assembly and release of the virus. PEDV
also utilizes the p38 MAPK and JNK signaling pathways for optimal
replication. Similarly, PEDV infection induces endoplasmic reticulum
(ER) stress response and activation of NF-κB signal also contributes to
PEDV replication. Additionally, PEDV can facilitate its replication by
affecting autophagy. Note: ↑, ↓ in the figure denote promotion or
inhibition, respectively.