Figure legend:
Fig 1: The involvement of numerous host factors and viral proteins in the different processes of PEDV infection . During the process of virus attachment and entry into cells, the host factors pAPN, HS, sialic acid, EGFR, TMPRSS2, MSPL and occludin are found to promote PEDV infection by interacting with the S protein. DC-SIGN and DPP4 may play a role in this process as well, while more robust evidence is needed. HnRNPA1 and NPM1 are verified to interact with the N protein of PEDV, thus participating in the transcription and replication stages. Finally, TMPRSS2 and BST2 are identified to take part in the assembly and release of the virus. PEDV also utilizes the p38 MAPK and JNK signaling pathways for optimal replication. Similarly, PEDV infection induces endoplasmic reticulum (ER) stress response and activation of NF-κB signal also contributes to PEDV replication. Additionally, PEDV can facilitate its replication by affecting autophagy. Note: ↑, ↓ in the figure denote promotion or inhibition, respectively.