Secondary outcomes  
The time interval between the achievement of euthyroid status and observed effects on ejaculatory function among subjects in the studies, presence of need for further treatment except intervention aimed at euthyroidism for related EjD, treatment-related sexual side effects (de novo ED or loss of libido, etc.), and economic aspects of treatment to achieve changes in ejaculatory function were the secondary outcomes if reported in eligible studies.
Synthesis of results: Data of eligible articles were extracted into Excel sheets and analyzed for quality, the quantity of the measured effect, the direction of the effect, and rated according to the possible risk of bias.
Additional analysis: The random effects model was used for all measures obtained from eligible studies. Measures of intervention effect on outcomes with change over time or differences between groups were the main aim of the current meta-analysis. We initially evaluated the consistency of standardized correlation coefficients between the IELT and serum TSH measurements of the subjects across studies. Observed effect measures (p values) with 95% confidence intervals, measured effects of thyroid dysfunction treatment with odds ratios, and PRO and IELT measurements were analyzed. While different methods were anticipated to be used in the measurement of IELT and PRO measures of the heterogeneous group of subjects across the eligible studies, a standardized mean difference was used to estimate the overall size of the effect on the measured variable. We have used “Review Manager (RevMan)” computer program Version 5.4 for windows from “Cochrane Collaboration, 2020” and Open Meta program (http://www.cebm.brown.edu/open_meta) during our study conduction. Both of these programs have already been launched for the use of external reviewers.