ABSTRACT
INTRODUCTION: We evaluated the re-transurethral resection
(re-TUR) pathologies and the comparison of pathology results between
transurethral resection of bladder (TUR-B) and re-TUR for non-muscle
invasive bladder cancer (NMIBC). Additionally we assessed the factors
affecting the re-TUR pathology and tried to define the more valuable
re-TUR patient groups. We also aimed to evaluate the effect of re-TUR on
recurrence and progression.
METHODS: We performed re-TUR to intermediate/high risk NMIBC
patients, 4-6 weeks after the index TUR-B. Both TUR-B and re-TUR
pathology characteristics, including tumor stage, grade, size, number,
lymphovascular invasion (LVI), carcinoma in situ (CIS), variant
pathology and intermediate/high risk status were analysed. The
recurrence and progression rates were also evaluated according to
re-TUR.
RESULTS: A total of 78 patients with NMIBC were included to the
study. The index TUR-B pathologies were Ta-Low: 6 (7,7%), Ta-High: 5
(6,4%), T1-Low: 14 (17,9%), T1-High: 53 (67,9%). Re-TUR positivity
was n: 40 (51 %), and upstaging/upgrading at re-TUR was n: 11 (14 %)
in all groups. Re-TUR positivity was significantly higher in high-risk
compared to intermediate-risk NMIBC (p:0,026). Re-TUR positivity was
higher in patients with hydronephrosis, CIS, LVI, differentiation, size
(>3 cm) and multiple tumour presence (p<0,05).
There was no significant relationship between recurrence / progression
and re-TUR (p>0,05).
CONCLUSION: Residual tumour was common after the index TUR-B
and upstaging after re-TUR was very important. Re-TUR is critically
important in high-risk NMIBC, presence of hydronephrosis, CIS, LVI,
variant pathology, size (>3 cm) and multiple number of
tumor.
Keywords: Bladder Cancer, Tur-B, Re-Tur, Pathology