Figure 2. AlphaFold-Multimer solutions contain a putative transacylaton site. a) Two predictions for the ACP+KS dimer from PikMod6 show ACP binding to the putative transacylation site either in trans or in cis . b) The top AlphaFold-Multimer prediction for the first ACP+KS+AT of the Erythromycin PKS, Ery(ACP1+KS1+AT2), superposed on the cryo-EM structure of Ery(KS1+AT2+KR2+ACP2) in which EryACP2 was observed bound at the extension site (PDB: 7M7F, EryKR2 not shown).