Conclusion
In conclusion, the low risk result of cfDNA screening is acceptable for patients with NT between 95th and 99th percentile. Therefore, cfDNA screening in pregnant women with NT between 95th and 99th percentile may be considered as an acceptable alternative to invasive test for women intending to avoid the risk of miscarriage, although the procedure related risks of miscarriage after CVS and amniocentesis are low (0.1%) [26].