5  CONCLUSION
Our study clinically confirmed the correlation between AA HSCs depletion and abnormal IP, so the hypothesis of the onset of AA caused by abnormal IP deserves further research. If this assumption is confirmed, the specific depletion of HSCs mediated by immune disorder of AA is able to be reasonably explained as the loss of HSCs under stress owing to the impaired immune tolerance microenvironment provided by IP to HSCs (Figure 6), being expected to break the bottleneck in the study of the pathogenesis of AA.