Impaired Immune Privilege Exclusive to HSCs Mediated by Tregs is
associated with HSCs Exhaustion in children with Aplastic Anemia
Can Huang1#,
Shanshan Li1#, Jingwei Yang1,
Xuelian Liao1, Yangyang Jiao1, Ting
Zhang1, Shuanglong Lu2, Yanhua
Li1, Hui Jiang1*, Fanyi
Zeng3,4*, Shayi Jiang1,4*
1Department of Hematology and Oncology, Shanghai
Children’s Hospital, School of Medicine, Shanghai Jiao Tong University,
Shanghai, China
2Department of Pediatrics, Tongji Hospital, Tongji
University School of Medicine, Shanghai, China
3Shanghai Institute of Medical Genetics, Shanghai
Children’s Hospital, & Department of Histo-Embryology, Genetics and
Developmental Biology, Shanghai Jiao Tong University School of Medicine,
Shanghai, China
4NHC Key Laboratory of Medical Embryogenesis and
Developmental Molecular Biology & Shanghai Key Laboratory of Embryo and
Reproduction Engineering, Shanghai, China
#These authors contribute equally to the work
Running head: HSCs Loss Protection of immune privilege