3.3 Th1/Th2 imbalance in AA
The normal IP effect also involves homeostasis between Th1 and Th2 with
a predominance action of Th2 cells and a relatively low activity of Th1
and Th1710, so Th1/Th2 can indirectly reflect IP
function11. Th17 cells are also considered to be
similar to Th1 cells in the regulation of immune tolerance. Compared
with the normal control, AA group showed a significantly higher
proportion of Th1 and a lower Th2 in bone marrow (for Th1 39.80%±5.20%vs . 22.1%±2.9%, P <0.0001; Th2 59.20%±5.30%vs . 77.20%±2.60%, P <0.0001), with a Th1/Th2
shift. Meanwhile Th17 was also lower in AA group than that in control
group (1.00%±0.60% vs . 0.50%±0.70%, P =0.0047) (Figure
3).
For Th1/Th2 in peripheral blood of AA, it was also higher than that in
the control group, but there was no statistically significant difference
(P >0.05) (data not shown). The predominance Th1 of
bone marrow also supported the weakening of the local immune tolerance
environment.