5 CONCLUSION
Our study clinically confirmed the correlation between AA HSCs depletion
and abnormal IP, so the hypothesis of the onset of AA caused by abnormal
IP deserves further research. If this assumption is confirmed, the
specific depletion of HSCs mediated by immune disorder of AA is able
to be reasonably explained as the loss of HSCs under stress owing to the
impaired immune tolerance microenvironment provided by IP to HSCs
(Figure 6), being expected to break the bottleneck in the study of the
pathogenesis of AA.