METHODS
This study was conducted at the HSCT Unit of Hospital Pequeno PrÃncipe
in Curitiba, Brazil, one of the largest pediatric HSCT centers in
Brazil. Mostly financed by public resources, the center has been
performing autologous HSCTs since 2011. Subsequently, allo-HSCT was
established for matched sibling donors (MSD) (2013), haploidentical
donors (2014), and unrelated donors (2017). This is a retrospective
study based on descriptive and quantitative analyses. Data was obtained
from the hospital database with prior local Ethics Committee approval
(3.318.929).
Patient cohort
From January 2013 to December 2018, 122 patients under 18 years of age
underwent allo-HSCT. From this initial group, those who experienced
primary graft failure (n=7), received stem cells from umbilical cord
blood (n=3) or did not undergo a conditioning regimen (n=1) were
excluded. The final cohort included 111 patients. For lymphocyte
recovery analysis, patients who experienced secondary graft failure or
relapse, those who died before each cut-off day, and those with
incomplete history were also excluded.