Inclusion and Exclusion Criteria
The inclusion criteria were: 1. diagnose of PE by elevated blood
pressure (Systolic pressure≥140mmHg or diastolic pressure≥90, and with
proteinuria) after 20 weeks of gestational age according to the ACOG
guidelines (2019); 2. diagnose with PE accompanied with fetal growth
restriction (FGR); 3. Maternal age ranging from 18 to 45 years; 4.
Gestational age ≥28 weeks. Moreover, severe PE was diagnosed as 1)
systolic pressure≥160 mmHg or diastolic pressure≥110 mmHg, measured at
least every 4 hours; 2) platelet
count≤100*109/L; 3) abnormal liver function (elevated
liver enzymes twice the upper limit) without other diseases; 4) renal
dysfunction (Scr≥97.24 μmol/L) in the absence of other diseases; 5)
pneumonedema; 6) new-onset headache without other diseases; 7) blurred
vision19. FGR was
defined as an infant birthweight below the 10thpercentile of the average of infants at the same gestational age.
Patients without any complications during the perinatal period were
eligible for enrolment in the normal group.
The exclusion criteria were as follows: 1. presence of other
complications, such as gestational diabetes mellitus, chronic
hypertension, intrahepatic cholestasis of pregnancy, and
hyperthyroidism; 2. Preterm (gestational age less than
36+6 weeks) not caused by PE; 3. Pre-existing mental
diseases, history of depression, or family depression; 4. Stillbirth or
giving birth to a malformed fetus (including any minor anomalies).