3.1 | Study population
The characteristics and laboratory data for the AD patients and HCs are shown in Table S1. The number of AD patients was 38 and the median age was 45.5 (20–63) years. The male-to-female ratio was 25 (65.8%) to 13 (34.2%). Disease duration was 36.0 (6–57) years. Median EASI score was 18.5 (1.0–54.3). Median total serum IgE was 6336.3 IU/mL. Complications with other allergic diseases were allergic rhinitis in 17 (45.0%), asthma in 16 (42.1%), food allergy in 11 (29.0%), allergic conjunctivitis in 7 (18%), and urticaria in 6 (15.8%). The number of HCs was 21 and the median age was 29.0 (26–46) years. The male-to-female ratio was 7 (33.3%) to 14 (66.7%).
3.2 | Analysis of c linical and laboratory factors in AD patients
Clinical factors, disease severity reflected by EASI scores,35 and laboratory factors including thymus and activation-regulated chemokine (TARC), lactate dehydrogenase (LDH), and total serum IgE were analyzed in AD patients.36 Among the AD patients, moderate positive correlations were observed between EASI score and TARC (rs = .50) and between EASI score and LDH (rs = .67) (Figure 1 A, B). Although not statistically significant, there was a mild positive correlation between EASI score and total serum IgE (rs = .31) (Figure 1 C).