Interacting drugs Interacting active principles Interaction severity Interaction effects
CNS medications Alprazolam-codeine or morphine Major Increased risk of CNS- and respiratory system depression.
Alprazolam-furosemide Moderate Increased risk of hypotension.
Alprazolam-omeprazole Moderate Increased blood levels of alprazolam.
Alprazolam-trazodone Moderate Increased risk of CNS- and respiratory system depression.
Citalopram-promazine Major Increased risk of QT ECG prolongation.
Citalopram-quetiapine Major Increased risk of QT ECG prolongation.
Clonazepam-dexmedetomidine Moderate Increased risk of CNS- and respiratory system depression.
Clonazepam-spironolactone Moderate Increased risk of hypotension.
Clonazepam-propofol Moderate Increased risk of CNS- and respiratory system depression.
Clonazepam-risperidone Moderate Increased risk of CNS- and respiratory system depression.
Codeine-morphine Major Increased risk of CNS- and respiratory system depression.
Codeine-trazodone Moderate Increased risk of serotonin syndrome.
Codeine-valproic acid Moderate Increased risk of CNS- and respiratory system depression.
Dexmedetomidine-amlodipine Moderate Increased risk of hypotension.
Dexmedetomidine-midazolam Moderate Increased risk of CNS- and respiratory system depression.
Dexmedetomidine-olanzapine Moderate Increased risk of CNS- and respiratory system depression.
Dexmedetomidine-propofol Moderate Increased risk of CNS- and respiratory system depression.
Dexmedetomidine-ramipril Moderate Increased risk of hypotension.
Dexmedetomidine-risperidone Moderate Increased risk of CNS- and respiratory system depression.
Dexmedetomidine-spironolactone Moderate Increased risk of hypotension.
Haloperidol-verapamil Moderate Increased risk of hypotension.
Lorazepam-bisoprolol Moderate Increased risk of hypotension.
Lorazepam-furosemide Moderate Increased risk of hypotension.
Lorazepam-haloperidol Moderate Increased risk of CNS- and/or respiratory-depressant effects.
Lorazepam-olanzapine Major Increased CNS- and CV-depressant effects (i.e., low blood pressure, weak pulse, muscle weakness, drowsiness, and dizziness).
Lorazepam-risperidone Moderate Increased CNS- and/or respiratory-depressant effects may be additively or synergistically.
Lorazepam-tamsulosin Moderate Increased risk of hypotension.
Midazolam-propofol Moderate Increased risk of CNS- and respiratory system depression.
Midazolam-spironolactone Moderate Increased risk of hypotension.
Morphine-trazodone Moderate Increased risk of CNS- and respiratory system depression.
Olanzapine-amlodipine Moderate Increased risk of hypotension.
Olanzapine-bisoprolol Moderate Increased risk of hypotension.
Olanzapine-citalopram Moderate Increased risk of QT ECG prolongation.
Olanzapine-clonazepam Major Increased risk of CNS depression.
Olanzapine-midazolam Major Increased risk of CNS depression.
Olanzapine-promazine Moderate Increased risk of paralytic ileus, hyperthermia, heat stroke, and anticholinergic intoxication syndrome.
Olanzapine-propofol Moderate Increased risk of QT ECG prolongation.
Olanzapine-quetiapine Moderate Increased risk of paralytic ileus, hyperthermia, heat stroke, and anticholinergic intoxication syndrome.
Olanzapine-spironolactone Moderate Increased risk of hypotension.
Promazine-bisoprolol Moderate Increased risk of hypotension.
Promazine-quetiapine Moderate Increased risk of QT ECG prolongation.
Quetiapine-bisoprolol Moderate Increased risk of hypotension.
Risperidone-amlodipine Moderate Increased risk of hypotension.
Risperidone-olanzapine Moderate Increased risk of paralytic ileus, hyperthermia, heat stroke, and anticholinergic intoxication syndrome.
Risperidone-midazolam Moderate Increased risk of CNS- and respiratory system depression
Risperidone-propofol Moderate Increased risk of QT ECG prolongation.
Risperidone-spironolactone Moderate Increased risk of hypotension.
Sertraline-furosemide Moderate Increased risk of hyponatraemia.
Sertraline-loperamide Moderate Increased risk of QT ECG prolongation.
Sertraline-lorazepam Moderate Increased CNS- and/or respiratory-depressant effects may be additively or synergistically.
Sertraline-olanzapine Moderate Increased risk of QT ECG prolongation.
Sertraline-risperidone Moderate Increased risk of QT ECG prolongation.
Sertraline-tamsulosin Moderate Increased blood levels of tamsulosin due to sertraline inhibition of CYP450 3A4 and/or 2D6 and increased risk of hypotension.
Trazodone-citalopram Major Increased risk of serotonin syndrome and of QT ECG prolongation.
Valproic acid-clonazepam Moderate Increased risk of drowsiness and seizures.
Valproic acid-haloperidol Moderate Increased risk of CNS- and/or respiratory-depressant effects.
Valproic acid-dexmedetomidine Moderate Increased risk of CNS- and/or respiratory-depressant effects.
Valproic acid-morphine Moderate Increased risk of CNS-depressant effects.
Valproic acid-olanzapine Moderate Increased risk of hepatic toxicity.
Valproic acid-propofol Moderate Increased blood levels of propofol.
Valproic acid-risperidone Moderate Increased blood levels of valproic acid.
Valproic acid-trazodone Moderate Increased risk of CNS- and/or respiratory-depressant effects.
CV medications Acetylsalicylic acid-amlodipine Moderate Increased risk of hypertension.
Acetylsalicylic acid-enoxaparin Major Increased risk of bleeding.
Acetylsalicylic acid-betamethasone or methylprednisolone Moderate Reduced serum concentrations and therapeutic effects of salicylates.
Acetylsalicylic acid-candesartan Moderate Increased risk of candesartan inefficacy due to acetylsalicylic acid-related inhibition of renal prostaglandin synthesis.
Acetylsalicylic acid-citalopram Moderate Increased risk of bleeding.
Acetylsalicylic acid-losartan or valsartan Moderate Increased risk of losartan inefficacy due to acetylsalicylic acid-related inhibition of renal prostaglandin synthesis.
Acetylsalicylic acid-sertraline Moderate Increased risk of bleeding.
Acetylsalicylic acid-verapamil Moderate Increased blood levels of valproic acid.
Acetylsalicylic acid-verapamil Moderate Increased risk of bleeding, bruising, headache, dizziness, weakness.
Amiodarone-furosemide Major Increased risk of QT ECG prolongation.
Amiodarone-warfarin Major Increased risk of bleeding.
Atorvastatin-amiodarone Moderate Increased blood levels of atorvastatin and increased risk of myopathy.
Atorvastatin-bicalutamide Moderate Increased blood levels of atorvastatin and increased risk of myopathy.
Atorvastatin-pantoprazole Moderate Increased blood levels of atorvastatin and increased risk of liver damage and myopathy due to competitive inhibition of intestinal P-glycoprotein and CYP450 3A4.
Bisoprolol-alprazolam Moderate Increased risk of hypotension.
Bisoprolol-gliclazide Moderate Increased risk of hypoglycaemia.
Bisoprolol-furosemide Moderate Increased risk of hyperglycaemia and hypertriglyceridemia.
Bisoprolol-linezolid Moderate Increased risk of hypotension, orthostasis, bradycardia, and heart failure.
Bisoprolol-methylprednisolone Moderate Increased risk of bisoprolol inefficacy due to corticosteroids-related sodium and fluid retention.
Candesartan-enoxaparin Moderate Increased risk of hyperkalaemia.
Candesartan-betamethasone Moderate Increased risk of candesartan inefficacy due to corticosteroids-related sodium and fluid retention.
Clopidogrel-atorvastatin Moderate Decreased efficacy of clopidogrel due to a mechanism of competitive inhibition of CYP450 3A4.
Clopidogrel-citalopram Moderate Increased risk of bleeding.
Losartan-betamethasone Moderate Increased risk of losartan inefficacy due to corticosteroids-related sodium and fluid retention.
Olmesartan-potassium chloride Major Increased risk of hyperkalaemia.
Perindopril-furosemide Moderate Increased risk of hypotension and hypovolemia.
Perindopril-glicazide Moderate Increased risk of hypoglycaemia.
Perindopril-insulin Moderate Increased risk of hypoglycaemia.
Perindopril-metformin Moderate Increased risk of hypoglycaemia.
Perindopril-vildagliptin Moderate Increased risk of angioedema.
Ramipril-allopurinol Major Increased risk of severe hypersensitivity reactions, neutropenia, agranulocytosis, and serious infections.
Ramipril-clonazepam Moderate Increased risk of hypotension.
Ramipril-olanzapine Moderate Increased risk of hypotension.
Ramipril-risperidone Moderate Increased risk of hypotension.
Ramipril-spironolactone Major Increased risk of hyperkalaemia.
Ramipril-vildagliptin Moderate Increased risk of angioedema.
Warfarin-amoxicillin/clavulanate Moderate Increased risk of bleeding.
Warfarin-rabeprazole or pantoprazole Moderate Increased risk of bleeding.
Other interactions Fluticasone propionate/vilanterol-linezolid Moderate Increased risk of hypertension, palpitation, tachycardia, and chest pain.
Furosemide-ceftriaxone Moderate Increased risk of nephrotoxicity.
Furosemide-gliclazide Moderate Increased risk of hyperglycaemia.
Furosemide-insulin Moderate Increased risk of hyperglycaemia.
Furosemide-linezolid Moderate Increased risk of hypotension and orthostasis.
Furosemide-methylprednisolone Moderate Increased risk of hypokalaemia.
Furosemide-pantoprazole or esomeprazole Moderate Increased risk of hypomagnesemia.
Furosemide-vildagliptin Moderate Increased risk of hyperglycaemia.
Gliclazide-furosemide Moderate Increased risk of hyperglycaemia.
Insulin-gliclazide Moderate Increased risk of hypoglycaemia.
Insulin-vildagliptin Moderate Increased risk of hypoglycaemia.
Vildagliptin-gliclazide Moderate Increased risk of hypoglycaemia.