Gastrointestinal and hepatic disorders
We observed four cases of GI and hepatic disorders, in particular “nausea”, “vomiting”, “diarrhoea” and “hypertransaminasemia”. In these cases, all classes of COVID-19 medications were involved and GI intolerance often led to pharmacological switching between the associations lopinavir/ritonavir and darunavir/cobicistat. This kind of non-specific ADRs is frequently (common or very common ) observed for all medication classes, including that of COVID-19 treatments [30, 36-38, 52]. The evaluation of causality assessment for GI and hepatic disorders must take into consideration the presence of concomitant medications and the underlying SARS-CoV-2 infection, which is commonly associated with GI symptoms [53].