Results
Clinical course of EAE
The mice developed clinical signs of EAE on day 10(onset) p.i. and on day 22 p.i.(peak), the symptoms of EAE peaked, with an average score of 3.00±0.37. The signs began to ease gradually on day 25(recovery). The weight of EAE group gradually decreased until the lowest point on day 22 p.i.(peak), and then increased gradually, which was consistent with the changes of symptoms. Mice in the control group showed no clinical sign(P<0.0001). (Figure 1a).