Abbreviations
ALT, alanine transaminase; ANIT, α-naphthylisothiocyanate; AP, alkaline
phosphatase;AST, aspartate transaminase; ATP,adenosine triphosphate ;
BDL, bile duct ligation; BMDMs, bone marrow-derived macrophages; Bsep,
bile salt export pump; CCR-2, C–C chemokine receptor type-2; CLD,
cholestatic liver disease; DDC,
3,5-diethoxycarbonyl-1,4-dihydrocollidine; FXR, farnesoid X receptor;
γ-GT, γ-glutamyltransferase; IL-1β, interleukin 1 beta; KCs, Kupffer
cells; LPS, lipopolysaccharide; LXR, liver X receptor; MCP, monocyte
chemoattractant protein; NFκb, nuclear factor κB; OCA, obeticholic acid;
PBC, primary biliary cholangitis; PPARγ, peroxisome
proliferator-activated receptor-γ; PSC, primary sclerosing cholangitis;
TBA, total bile acids; TCMs, traditional chinese medicines; TEC,
tectorigenin; TZDs,thiazolidinedione compounds; UDCA, ursodeoxycholic
acid.
This work was supported by grants from Natural Science Foundation of
Tianjin (19JCQNJC12600); Research project of Tianjin education
commission (2019KJ044).