Unstructured Abstract
Five-fluorouracil (5-FU) and platins remain a first line treatment in
oncology with a potential of cardiovascular toxicity. We identified two
cases of acute severe cardiac toxicity treated with a combination of
5-FU (different production batch) and platins at three months interval
at two different institutions referred to our cardio-oncology services.
Both cases had similar clinical presentation, favorable outcomes and
identical cardiac magnetic imaging scans at follow-up. Mechanism was
direct myocardial toxicity in the case with endomyocardial biopsy.
Circulatory support as a bridge to recovery should be considered in the
case of untreatable cardiogenic shock likely due to 5-FU.