3.Results
3.1Identification of differentially expressed miRNAs /
differentially expressed genes
We compared the miRNA and mRNA expression profiles of the whole blood
samples obtained from the 5 patients with BPD and 6 healthy controls.
After statistical validation, the results of NetworkAnalyst analysis
showed that there were 19 significant DEMs identified. Among them, 10
DEMs were upregulated, whereas 9 DEMs were downregulated (Table 1). In
total, 207 DEGs were identified, including 168 upregulated and 39
downregulated (Appendix 1). The distribution of whole DEGs is shown in
volcano plots (Fig. 1B), while the top 50 DEGs are shown in a heatmap
(Fig. 1A).