2.1 Microarray data
GEO (http://www.ncbi.nlm.nih.gov/geo) is a public functional genomics data repository containing array- and sequence-based data (Clough and Barrett, 2016). The GSE108754 gene expression profiles and the GSE108755 miRNA expression profiles were downloaded from GEO. A total of 20 premature infants with BPD and 20 non-BPD age-matched controls were enrolled from NICU in Shanghai Children Hospital from January 2015 to December 2016. BPD is diagnosed according to the National Institute of Child Health and Human Development (NICHD) guidelines in 2001. There was no significant difference in general clinical data between the two groups. Peripheral blood samples were collected. 5 infants with BPD and 6 infants without BPD were randomly selected for screening DEMs and DEGs, the others were used to verify. The array data were based on the GPL17107 Exiqon miRCURY LNA™ microRNA Array - hsa, mmu & rno (Bethesda, MD, USA) and GPL13497 Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version) (Palo Alto, CA, USA). Moreover, we compared the results of GSE125873 and GSE32472 with our analysis.