3.2 GO and KEGG pathway enrichment of differentially expressed
mRNAs
In total, 479 downregulated and 746 up-regulated mRNAs were analyzed
with GO and KEGG pathway enrichment analysis. For downregulated genes,
there were 35 GO enrichment processes with FDR<0.01. The top
ten enriched BP were mainly related to immune and inflammation
processes, such as, positive regulation of natural killer cell mediated
cytotoxicity, and response to lipopolysaccharide (Figure 2A, E-Table 5).
Furthermore, there were 7 enriched KEGG pathways with
FDR<0.01, and these pathways were also largely related to
immune and inflammation processes: cytokine-cytokine receptor
interaction, natural killer cell mediated cytotoxicity, and Toll-like
receptor signaling pathway (Figure 2B, E-Table 6). For the 746
upregulated genes, there were 62 GO enrichment processes with
FDR<0.01. The top ten enriched BP were primarily related to
heart muscle signal transduction, gluconeogenesis, and glycolysis
processes (Figure 2C, E-Table 7). There were 9 enriched KEGG pathways
with FDR<0.01 and these pathways were mainly related to
olfactory transduction, ECM-receptor interaction, PPAR signaling
pathway, cell Communication, gluconeogenesis and glycolysis pathways
(Figure 2D, E-Table 8).