Fig. 1. CD27+IgD+B cells are
decreased in the blood of patients with SLE compared to healthy
controls. (A) Gating strategy to identify naïve B cells
(CD27-IgD+), Innate-like B cells
(CD27+IgD+), switched memory B cells
(CD27+IgD-), and double negative B
cells (CD27-IgD-) in human blood.
(B) CD27+IgD+B cells from a
representative healthy control (left panel) and an SLE patient (right
panel). (C) Percentage of CD27+IgD+B cells in patients with SLE(n=50)and healthy controls(n=50).
Data are represented as mean ± SD or median ± interquartile range. Data
points represent individual subjects. NS = not significant,
**p<0.01, ***p<0.001