Figure 3 Difference of dampened IgM-producing capacities of CD27+IgD+B cells between SLE and normal control. Flow cytometry-sorted CD27+IgD+B cells from four healthy donors and four active SLE patients (SLEDAI>5) were subjected to ELISPOT (A) Real-time PCR (B) analyses of IgM. The representative charts as well as the statistical results were shown (t-test, *P < 0.05, ***P < 0.001).