Fig. 1. CD27+IgD+B cells are decreased in the blood of patients with SLE compared to healthy controls. (A) Gating strategy to identify naïve B cells (CD27-IgD+), Innate-like B cells (CD27+IgD+), switched memory B cells (CD27+IgD-), and double negative B cells (CD27-IgD-) in human blood. (B) CD27+IgD+B cells from a representative healthy control (left panel) and an SLE patient (right panel). (C) Percentage of CD27+IgD+B cells in patients with SLE(n=50)and healthy controls(n=50).
Data are represented as mean ± SD or median ± interquartile range. Data points represent individual subjects. NS = not significant, **p<0.01, ***p<0.001