Statistics analysis
SPSS 17.0 (SPSS, USA) was employed for data analysis. Student’s t-test,
paired t-test, one-way ANOVA and Spearman rank correlation,
respectively, were performed for statistical analysis as appropriate.
P<0.05 indicated statistical significance.ResultsCD27+IgD+B cell amounts are significantly decreased in SLE patients
B cells were grouped into 4 subtypes according to CD27 and IgD levels,
including naïve (CD27-IgD+),
innate-like (CD27+IgD+), switched
memory (CD27+IgD-) and double
negative (CD27-IgD-) B cells (Figure
1A). To examine the function of
CD27+IgD+B cells in SLE
pathogenesis, their amounts were firstly compared between SLE and HC
patients. The 50 HCs showed remarkably higher circulatory
CD27+IgD+B cell amounts compared
with the 50 individuals with SLE (Figure 1B and C).