Fig. 1. Circulatory CD27+IgD+B cell amounts are reduced in SLE cases in comparison with healthy control (HC) patients. (A) Gating strategy for identifying naïve (CD27-IgD+), innate-like (CD27+IgD+), switched memory (CD27+IgD-) and double negative (CD27-IgD-) B cells in human blood. (B) CD27+IgD+B cells obtained from representative HC (left panel) and SLE (right panel) patients. (C) Percentages of CD27+IgD+ B cells in SLE (n=50) and HC (n=50) patients.
Data are mean±SD or median and interquartile range. Data points represent individual participants. NS, not significant. **p<0.01, ***p<0.001