Figure 8: Open state structure of the human Nav1.5 sodium channel.
(A) Top view of the Cryo-EM structure of rat Nav1.5 channel showing the IFM motif in red spheres. (B) Bottom view of the Cryo-EM structure of the rat Nav1.5 channel showing the IFM motif in red spheres. (C) Close-up view of the IFM motif flanked by G1481 on the N-terminal and Q1491 on the C-terminal. A strong hydrogen bond between N1661 and Q1491 (2.9A) ensures the proper docking of IFM motif.