Novel G1481V and Q1491H SCN5A mutations linked to long QT
syndrome destabilize the Nav1.5 inactivation state
Plumereau Q.1, Theriault
O.1, Pouliot V.1, Moreau
A.2, Morel E.3, Fressart
V.4, Denjoy I.5, Delinière
A.3, Bessière F3, Chevalier
P.3,6,7, Gamal El-Din TM.8 and*Chahine M. 1,9
1CERVO Brain Research Center, Quebec City, QC, Canada
2Inserm U1046, CNRS UMR 9214, Université de
Montpellier, Montpellier, France
3Lyon Reference Center for Inherited Arrhythmias,
Louis Pradel Cardiovascular Hospital, Bron, France
4Centre de génétique moléculaire et chromosomique,
Hôpital Pitié-Salpêtrière, Paris, France
5Hôpital Bichat Claude Bernard, Paris, France
6Department of Rhythmology, Louis Pradel
Cardiovascular Hospital, Lyon, France
7Université de Lyon, Lyon, France
8Department of Pharmacology, University of Washington,
Seattle, WA 98195, USA.
9Department of Medicine, Faculty of Medicine,
Université Laval, Quebec City, QC, Canada