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Emerging role of cysteinyl leukotrienes in cancer
  • Lou Saier,
  • Olivier Peyruchaud
Lou Saier
INSERM U1033
Author Profile
Olivier Peyruchaud
INSERM
Author Profile

Abstract

Cysteinyl leukotrienes (CysLTs) are inflammatory lipid mediators that play a central role in the pathophysiology of several inflammatory diseases. Recently, there has been an increased interest in determining how these lipid mediators orchestrate tumor development and metastasis through promoting a pro-tumoral microenvironment. Upregulation of CysLTs receptors and CysLTs production is found in a number of cancers and has been associated with increased tumorigenesis. Understanding the molecular mechanisms underlying the role of CysLTs and their receptors in cancer progression will help investigate the potential of targeting CysLTs signaling for anti-cancer therapy. This review gives an overview of the biological effects of CysLTs and their receptors, along with current knowledge of their regulation and expression. It also provides a recent update on the molecular mechanisms that have been postulated to explain their role in tumorigenesis and on the potential of anti-CysLTs in the treatment of cancer.

Peer review status:IN REVISION

07 Sep 2020Submitted to British Journal of Pharmacology
09 Sep 2020Assigned to Editor
09 Sep 2020Submission Checks Completed
17 Sep 2020Reviewer(s) Assigned
03 Nov 2020Review(s) Completed, Editorial Evaluation Pending
10 Nov 2020Editorial Decision: Revise Minor