LV indicates left ventricular; LA left atrium; RV right ventricular; RA right atrium; IVS interventricular septum; LVPW left ventricular posterior wall; AAO ascending aorta; PA pulmonary artery; EDV end-diastolic volume; ESV end-systolic volume; EF ejection fraction; AV aortic blood flow velocity; E peak mitral inflow early filling velocity; e’, early diastolic myocardial velocity; TAPSE Tricuspid annulus systolic displacement; TDI-s early systolic myocardial velocity; * compared with control group ,P< 0.05; # compared with mild patients,P< 0.05.