Lung function change during the study period according to the prognosis
We compared changes in FEV1% pred between Groups 1 and 2 and between Groups 3 and 4 during the study period (Table 3). A detailed description for the calculation is provided in theonline supplement . There was no significant difference in FEV1% pred change from pre-transplant to BOS diagnosis between Groups 1 and 2 and Groups 3 and 4. We compared changes in FEV1% pred at each time point with an interval of 3 months after BOS diagnosis during the study period, and there was a significant difference between Group 1 (-24.8±22.3%) and Group 2 (5.7±21.8%) (P =0.016) and between Group 3 (-19.4±24.4%) and Group 4 (8.6±21.9%) (P =0.041) during the first 3 months after BOS diagnosis. Likewise, there was a significant difference in the change of FEF25-75% pred between Group 1 (-32.4±23.6%) and Group 2 (11.7±37.1%) (P=0.007) and between Group 3 (-19.4±24.4%) and Group 4 (16.8±39.6%) (P=0.026) during the first 3 months after BOS diagnosis (E-table 4a). Detailed descriptions for additional analysis are provided in the online supplement (E-table 4b).