Lung function during the study period
Data gathered after lung TPL were excluded because they did not represent the original characteristics of the subjects. E-figure 1 shows the change in lung function caused by BOS. FEV1% pred, FVC% pred and FEF25-75% pred showed statistical significance during study period in linear mixed modeling, and FEV1% pred, FVC% pred, and FEF25-75% pred decreased significantly upon BOS diagnosis compared to pre-HSCT (P < 0.001). FEV% pred, FVC% pred, and FEF25-75% pred were 92.8±13.0%, 87.9±14.7%, and 113.0±24.2%, respectively, before HSCT, and FEV1% pred, FVC% pred, and FEF25-75% pred at the time of BOS diagnosis were 37.8±12.7%, 62.2±16.2%, and 16.4±9.6%, respectively. Among these values, FEF25-75% pred decreased the most from pre-HSCT (111.7±24.2%) to BOS diagnosis (16.0±3.3%). After BOS diagnosis, FEV1% pred, FVC% pred, and FEF25-75% pred were significantly reduced at each time point with an interval of 3 months during study period when compared to pre-HSCT (E-table 2).