3.1 | Clinical features
The clinical examination of four
probands from the four NSTA families all exhibited congenital
oligodontia, each missing 6-10 deciduous teeth and 8-18 permanent teeth
(excluding the third molars, Figure 1). The loss of permanent teeth was
confirmed by panoramic radiographs and found to be distributed
extensively in both dentitions. However, the shapes and sizes of the
residual teeth were normal. None of their parents (except the mother of
proband 4) had congenitally missing teeth, and mothers did not have
small or conical teeth. All participants reported normal sweating and
lachrymal secretions. They had no complaints of dry mouth, intolerance
to heat, or susceptibility to respiratory tract infections. The
participants had hair on the body and scalp, and their facial features,
skin, and nails were observed to be normal. (Figure 1).