Data analysis:
Descriptive statistics of variables were expressed as medians and
interquartile range (IQR), according to the analysis of the distribution
of data, while qualitative variables were summarized using frequency and
percentages. Second, ALT and AST values were analyzed in three periods:
before, during, and after the suspension of PP to establish differences
in these periods. For the overall analysis of the three periods the
Kruskal Wallis and Mann Whitney U tests were used to determine
differences between 2 periods (before vs. during, during vs. after, and
before vs. after). The Stata® v16 statistical software (Stata
Corporation, College Station, Texas, USA) was used for the analyses. A
value of p < 0.05 was considered statistically significant.
Ethical aspects :
The study protocol was approved by the Institutional Review Board of the
INSN-SB, under the institutional code PI-210-2018.