3.3 Latency of onset of rash to detection of human herpes viruses
We trended the days from the onset of rash to the first detection of the herpesviruses with a normal distribution as shown in Figure 1. The peak time from onset of disease to viral reactivation was around 11 days for EBV, 16 days for HHV6, and 23 days for CMV.

3.4 Predisposing factors for viral reactivation DRESS patients

To identify potential predisposing factors for viral reactivation, a comparative analysis of baseline characteristics between viral reactivated (n=39) and non-reactivated (n=54) groups was performed.(Supp Table 1) Our results showed that viral reactivation occurred independent of demographics, baseline co-morbidities, culprit drug and treatment. Of note, viral reactivation was observed in 15 out of 41 patients (37%) treated with topical steroids compared to 24 out of 49 (49%) patients treated with systemic corticosteroids (p=0.24).

3.5 Viral reactivation on DRESS phenotype and outcomes