Nevertheless, the proximity of the surrounding major cardiac structures might pose a risk of complications, and therefore, ablation within the LVS region may be challenging [7]. Important anatomical structures, such as surrounding coronary arteries, epicardial fat and fibrotic components, may complicate the approach [8]. Therefore, this review aims to give an extensive review of the anatomical terminology and procedural knowledge of LVS that may improve the understanding of this heart region to facilitate the performance of the radiofrequency ablation procedures.