Inside the LVS area, the presence of the great cardiac vein is almost inevitable. However, LVS may come without a coronary venous tributary when there is a short distance from the left coronary artery bifurcation to the first dominant septal perforator that excludes venous vessels from the defined LVS region (Figure 2B and Figure 3A,B). In anatomical terminology, the great cardiac vein begins at the heart’s apex. It ascends along the anterior interventricular groove to the base of the heart, while in cardiology and radiology, the initial segment of the great cardiac vein (from the apex of the left ventricle to the LVS area) is named the anterior intraventricular vein [22]. By definition, the anterior intraventricular vein originates at the lower or middle third of the anterior interventricular groove, follows the groove adjacent to the left anterior descending artery and angulates laterally toward the heart’s base to form the great cardiac vein [7,32]. The point of transition between the anterior interventricular vein and the great cardiac vein lies inside the LVS, and arguably, it is a significant source of epicardial idiopathic ventricular arrhythmias [33].