Ethics approval and registration
The present study was approved by
the Institutional Review Board of
the Peking Union Medical College Hospital, Chinese Academy of Medical
Science (date of approval: 28 August 2018; reference number: ZS-1678),
and was conducted in accordance with the
principles of the Declaration of
Helsinki and the CONSORT statement—as well as the RECOvER Checklist
requirement.12 This trial was registered with the
Chinese Clinical Trial Registry (www.chictr.org.cn), before the first
patient’s enrollment
(ChiCTR1800019066).