Ethics approval and registration
The present study was approved by the Institutional Review Board of the Peking Union Medical College Hospital, Chinese Academy of Medical Science (date of approval: 28 August 2018; reference number: ZS-1678), and was conducted in accordance with the principles of the Declaration of Helsinki and the CONSORT statement—as well as the RECOvER Checklist requirement.12 This trial was registered with the Chinese Clinical Trial Registry (www.chictr.org.cn), before the first patient’s enrollment (ChiCTR1800019066).