Recruitment
Between December 2018 and October 2019, a total of 397 women referred to the Peking Union Medical College Hospital were screened for eligibility. 243 women did not meet the inclusion criteria, and 10 women declined to participate in the trial. Of the 144 eligible women, 72 were randomly assigned to the intervention group and 72 to the control group (Fig. 1). Baseline characteristics of the two groups did not differ significantly (Table 1). Three patients withdrew their informed consent and 5 patients did not undergo eligible surgery. One patient with endometrial carcinoma allocated to control group had laparoscopic surgical staging instead of laparoscopic hysterectomy given the suspected myometrial invasion indicated by MR imaging. In addition, one laparoscopic myomectomy in the controlled group was converted to transabdominal hysterectomy due to intraoperative hemorrhage. After randomization, 67 women in the intervention group and 69 women in the control group completed their surgical procedures and received corresponding perioperative management (per-protocol analysis, Appendix S1).
Protocol compliance in both the groups is presented in Table 2. The compliance regarding key elements of the full ERAS program was significantly higher in the intervention group than in the control group.