Author Contributions
C.-L.L. performed data acquisition, statistical analyses, data interpretation, and drafted the manuscript. K.-S.L., S.-P.L. and H.-Y.L. participated in the study design and data interpretation and helped to draft the manuscript. C.-K.C. performed biochemical analyses and revised the manuscript. C.-H.S., H.-C.C. and R.-Y.T. were responsible for patient screening and revised the manuscript. All of the authors have read and have approved the final manuscript.