Successful treatment of 5-fluorouracil mediated cardiotoxicity
with uridine triacetate in a pediatric patient
Gisela Marrero-Rivera, MD; Cori Morrison, MD; Zachary LeBlanc, MD; Maria
Velez, MD; Dana LeBlanc, MD
Summary :
5-fluorouracil (5-FU) is a pyrimidine analogue used to treat adults with
a variety of carcinomas but less frequently used in pediatrics. This
chemotherapy has known cardiotoxic side effects, particularly among
adults with underlying cardiovascular disease, however this has rarely
been reported in the pediatric population. We report a rare case of 5-FU
induced cardiomyopathy in a pediatric patient with nasopharyngeal
carcinoma (NPC), successfully managed with milrinone and uridine
triacetate. This report underscores the need for prompt diagnosis and
treatment of 5-FU induced cardiomyopathy.