Successful treatment of 5-fluorouracil mediated cardiotoxicity with uridine triacetate in a pediatric patient
Gisela Marrero-Rivera, MD; Cori Morrison, MD; Zachary LeBlanc, MD; Maria Velez, MD; Dana LeBlanc, MD
Summary :
5-fluorouracil (5-FU) is a pyrimidine analogue used to treat adults with a variety of carcinomas but less frequently used in pediatrics. This chemotherapy has known cardiotoxic side effects, particularly among adults with underlying cardiovascular disease, however this has rarely been reported in the pediatric population. We report a rare case of 5-FU induced cardiomyopathy in a pediatric patient with nasopharyngeal carcinoma (NPC), successfully managed with milrinone and uridine triacetate. This report underscores the need for prompt diagnosis and treatment of 5-FU induced cardiomyopathy.