Current challenges
Although impressive progress has been made in revolutionizing the landscape of anti-cancer treatment through the development of cellular therapy, many challenges remain, such as ensuring successful leukapheresis and CAR T cell manufacturing, non-response and disease relapse, and managing its unique toxicity profile. Continued insights into these barriers will allow us to maximize the potential benefit of this powerful therapy with the goal of extending the application of CAR T cell therapy beyond B cell malignancies.