Results
There were 31 patients; 16 (51,6%) of them were female and 15 (48,4 %)
were male. The mean age was 36,2 (range 3-88) years. The histopathologic
subtypes were rhabdomyosarcoma, primitive neuroectodermal tumor,
osteosarcoma, chondrosarcoma, leiomyosarcoma, Ewing’s sarcoma and
synovyal sarcoma. The distribution of these sarcoma types has been shown
in Figure 1. The mean follow-up was 26,8 monhts (Min:12-Max:96 Months).
Tissue samples were firstly examined with hemotoxlylen-eosin. After this
evaluation subtyping was performed with imunophenotypic markers
including desmin, vimentin, myogenin and TLE-1. Desmin and myogenin were
seen possitive an immunohystochemical evaluation of A sample of
embrional rhabdomysarcoma which is formed from small-oval and round
cells at Figure 2. Chondrosarcoma was seen on the chondromixoid stroma
with seperated septa and formed with pleomorphic cells at Figure 3 and
TLE1 was seen possitive on an sample of the snovial sarcoma Figure 4.
The most frequent site was nasal cavity and was detected in 7 cases.
Other affected sites were maxilla (5 cases), neck (4 cases),
parapharyngeal region (1 cases), infratemporal fossa (2 cases), mandible
(3 cases), parotid region (2 cases), sphenoid sinus(1 case), malar
region (1 case), retrobulber region (2 cases), and larynx (3 cases)
(Figure 4). Definitive surgery was performed in 21 cases and 10 patients
were inoperable. Total laryngectomy were performed in two patients,
total maxillectomy in 6 cases, mandibulectomy and free flap
reconstruction in three cases, wide surgical resection in 10 cases.
Functional neck dissection was performed in eight cases. Surgical
margins were found to be positive in three of the 21 patients who
underwent surgical procedures and in 18 cases surgical margins were
negative.
Mean follow up was 26,8 months (Min: 12-Max:96 months). Adjuvant
chemotherapy was given to 10 cases and radiation treatment to 15 cases.
Chemotherapy was consisted of cisplatine, 5-FU, charboplatine,
vincristine for adults and vincristine, ifosfamide, Adriamycin,
etopocide, ciclofosfamide, charboplatine far pediatric patients. Drugs
were chosen according to the patients status.
Local recurrence developed in three patients. One of them was reoperated
and chemotherapy was given to the others. Seven of the patients died due
to distant metastases.