Results
There were 31 patients; 16 (51,6%) of them were female and 15 (48,4 %) were male. The mean age was 36,2 (range 3-88) years. The histopathologic subtypes were rhabdomyosarcoma, primitive neuroectodermal tumor, osteosarcoma, chondrosarcoma, leiomyosarcoma, Ewing’s sarcoma and synovyal sarcoma. The distribution of these sarcoma types has been shown in Figure 1. The mean follow-up was 26,8 monhts (Min:12-Max:96 Months). Tissue samples were firstly examined with hemotoxlylen-eosin. After this evaluation subtyping was performed with imunophenotypic markers including desmin, vimentin, myogenin and TLE-1. Desmin and myogenin were seen possitive an immunohystochemical evaluation of A sample of embrional rhabdomysarcoma which is formed from small-oval and round cells at Figure 2. Chondrosarcoma was seen on the chondromixoid stroma with seperated septa and formed with pleomorphic cells at Figure 3 and TLE1 was seen possitive on an sample of the snovial sarcoma Figure 4.
The most frequent site was nasal cavity and was detected in 7 cases. Other affected sites were maxilla (5 cases), neck (4 cases), parapharyngeal region (1 cases), infratemporal fossa (2 cases), mandible (3 cases), parotid region (2 cases), sphenoid sinus(1 case), malar region (1 case), retrobulber region (2 cases), and larynx (3 cases) (Figure 4). Definitive surgery was performed in 21 cases and 10 patients were inoperable. Total laryngectomy were performed in two patients, total maxillectomy in 6 cases, mandibulectomy and free flap reconstruction in three cases, wide surgical resection in 10 cases. Functional neck dissection was performed in eight cases. Surgical margins were found to be positive in three of the 21 patients who underwent surgical procedures and in 18 cases surgical margins were negative.
Mean follow up was 26,8 months (Min: 12-Max:96 months). Adjuvant chemotherapy was given to 10 cases and radiation treatment to 15 cases. Chemotherapy was consisted of cisplatine, 5-FU, charboplatine, vincristine for adults and vincristine, ifosfamide, Adriamycin, etopocide, ciclofosfamide, charboplatine far pediatric patients. Drugs were chosen according to the patients status.
Local recurrence developed in three patients. One of them was reoperated and chemotherapy was given to the others. Seven of the patients died due to distant metastases.