Correspondence:
Address: Dr. Ozgur Surmelioglu
Cukurova University
Faculty of Medicine
Department of Otorhinolaryngology
Adana/Turkey
Phone: +90 322 3386060
Mobile: +90 532 0557601
Fax: +90 322 3386527
e-mail: surmeli2004@yahoo.com
Background: Several prognostic factors can be used for the
evaluation of laryngeal cancer. The aim of this study to evaluate of the
predictive value of CD44 and ALDH1 expression for prognosis and
radiotherapy(RT) response in patients with early-stage laryngeal cancer
receiving RT.
Methods: Correlation between RT response and pre-treatment
immunohistochemical ALDH1 and CD44 staining was evaluated. In addition,
survival times were compared between groups.
Results: The mean age was found 59.8±9.0 years and 41 were
male. There were 20 patients in the non-recurrent group.
Immunohistochemical positivity for ALDH1 was found to be significant
risk factor for RT failure (p=0.0001), whereas CD44 positivity (p=0.114)
were not significant. Disease-free survival was shorter in cases with
positive ALDH1 and CD44 staining (p=0.0001).
Conclusion: ALDH1 positivity was identified as a significant
predictor of DFS and RT sensitivity.
Keywords: Laryngeal squamous cell carcinoma, ALDH1, CD44,
radiotherapy