Materials and Methods
Forty-five patients diagnosed as having early-stage laryngeal cancer and
treated with RT in the otorhinolaryngology department of XXX University
Faculty of Medicine between 2002 and 2016 were included in the study.
Patients were treated with curative radiotherapy with a linear
accelerator with a peak energy of 6 MV. All patients were treated
Patients were treated with 225 cGy /28 days in the same radiotherapy
center. The demographic and clinical data, pathology reports, prognostic
parameters, and survival rates of the patients were retrieved
retrospectively from their medical records. Among patients with
early-stage patients with recurrent and Cure with the same sampling were
studied. Patients with anterior commissure involvement were excluded
from the study. The patients were divided into two groups, those who
showed complete response with RT (non-recurrent group) and those who
developed local recurrence despite RT (recurrent group). The correlation
between treatment response and immunohistochemical staining for ALDH1
and CD44 at time of diagnosis was evaluated. Survival rates were also
compared between the groups.