Mechanism of Action
Mycophenolate mofetil (MMF) upon oral administration is hydrolyzed to mycophenolic acid (MPA) which is an active metabolite. It incorporates into the DNA and blocks the de novo pathway of guanosine nucleotide synthesis and reversibly inhibits inosine monophosphate dehydrogenase (IMPDH). It inhibits the proliferation of B and T lymphocytes as they are dependent upon the de novo synthesis of the purines [15, 17].