Mechanism of Action
Mycophenolate mofetil (MMF) upon oral administration is hydrolyzed to
mycophenolic acid (MPA) which is an active metabolite. It incorporates
into the DNA and blocks the de novo pathway of guanosine
nucleotide synthesis and reversibly inhibits inosine monophosphate
dehydrogenase (IMPDH). It inhibits the proliferation of B and T
lymphocytes as they are dependent upon the de novo synthesis of
the purines [15, 17].