Drug-Drug Interactions, Adverse Reactions & Contraindications
As per the U.S FDA, the antacid Maalox TC (magnesium and aluminium
hydroxide) when taken concomitantly reduces the absorption of
Mycophenolate Mofetil. it also reduces the area under the curve (AUC).
Moreover, a variation of the drug concentration in blood plasma over a
period of time also reduces the maximum serum concentration of the drug
(Cmax). All the above conditions are compared when MMF
is taken orally while fasting. In addition, persons who use MMF are at
increased risk of infections, including progressive multifocal
leukoencephalitis (PML) and opportunistic infection among renal, cardiac
and hepatic transplant patients. The use of MMF is contraindicated
during pregnancy as it can cause congenital malformations and
miscarriages [15].